Bioinformatics

From Bioinformatics, we will adapt existing tools in computational phylogenetics to the case of human mitochondrial DNA and to the identification of haplogroup related risks.

Specifically, we will be able to contrast existing studies in three directions: (i) pathogenic mutations present in neurodegenerative disease patients, (ii) increased or decreased risk of disease associated to different haplogroups and (iii) relationship of a higher mutation rate with disease progression.